Tyler and Perry performed with the Boston Pops Orchestra for their

Tyler and Perry performed with the Boston Pops Orchestra for their annual concert of July 4 on the Esplanade in 2006, a milestone as it was the first major event or performance since Steven Tyler’s throat surgery. Around this time, the band also announced that they would embark on the Route of All Evil Tour with Mötley Crüe in late 2006. On August 24, 2006, it was announced that Tom Hamilton was undergoing treatment for throat cancer . In order to make a full recovery, he sat out much of the Route of All Evil Tour until he was well again. Former Joe Perry Project bassist David Hull substituted for Hamilton until his return. On September 5, 2006, Aerosmith kicked off the Route of All Evil Tour with Mötley Crüe in Columbus, Ohio. The co-headlining tour took both bands to amphitheaters across North America through November 24, 2006. After that, a select few arena dates were added, some of which were with Mötley Crüe. The tour ended December 17, 2006.