While “Over My Head (Cable Car)” was rising on the charts, the song ” How to Save a Life ” was first featured during an episode of Grey’s Anatomy , aired March 19, 2006, and then on an episode of Scrubs , aired April 25, 2006. Despite not having been originally released as a single, “How to Save a Life” entered the Hot 100 chart on the issue marked April 15, 2006. The song was released as the band’s second single. On August 18, 2006, ABC announced that the song would be used for the main advertising promotion for the season premiere of Grey’s Anatomy .
How to Save a Life featured on Grey’s Anatomy
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